OKG (Nature's Bounty)
OKG (Nature's Bounty) - General Information
Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. OKG (Nature's Bounty) is a precursor of citrulline and arginine.
Pharmacology of OKG (Nature's Bounty)
A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.
OKG (Nature's Bounty) for patients
Dose should be taken before bedtime and on an empty stomach.
OKG (Nature's Bounty) Interactions
OKG (Nature's Bounty) Contraindications
L-Ornithine is contraindicated in those with a deficiency of ornithine-delta-aminotransferase.
L-Ornithine is contraindicated in those hypersensitive to any component of an ornithine-containing supplement.
Additional information about OKG (Nature's Bounty)
OKG (Nature's Bounty) Indication: Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
Mechanism Of Action: OKG (Nature's Bounty) is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Ornithine
Synonyms: 2,5-Diaminopentanoate; 2,5-Diaminopentanoic acid; 2,5-Diaminovaleric acid; Ornithine
Drug Category: Dietary supplement; Micronutrient; Non-Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Ornithine: OKG (Nature's Bounty);
Absorption: Absorbed from the small intestine via a sodium-dependent active transport process
Toxicity (Overdose): Oral, rat LD50 = 10000 mg/kg
Protein Binding: Not Available
Biotransformation: Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.
Half Life: Not Available
Dosage Forms of OKG (Nature's Bounty): Capsule Oral
Capsule Oral
Capsule Oral
Capsule Oral
Powder Oral
Chemical IUPAC Name: (2S)-2,5-diaminopentanoic acid
Chemical Formula: C5H12N2O2
L-Ornithine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
